Solving the medical challenge of MS won’t be easy.Get Curious
But Scripps Research employs world-class scientists, top technology…and determination…round the clock.
In the case of autoimmune disease, our normally tightly controlled immune system spins out of control, mistaking our own body as foreign and attacking different organs. One such autoimmune condition is multiple sclerosis (MS), a life-threatening and debilitating disease that affects approximately 2.5 million people worldwide, many diagnosed in their early twenties. In MS, immune cells attack the protective sheath around neurons, leading to nerve degeneration and disabilities from brain and spinal cord damage.
Due to the complexity of MS and other autoimmune disorders, doctors and scientists struggle to understand and treat them. They rank among the greatest medical challenges of our time. But scientists at Scripps Research are unraveling these mysterious diseases, steadily deciphering the genetic and environmental triggers of an abnormal immune system and devising ways to prevent damage and reverse the disease.
Our closely linked immunology and neuroscience researchers have joined forces with our leaders in drug discovery and clinical science. Together, the team is translating discoveries about our nervous system into groundbreaking therapies. This essential work seeks to reduce the global burden of MS and restore the lives of patients and their loved ones.
A Multidimensional Approach to Multiple Sclerosis
Slowing the Disease
In clinical trials, our breakthrough drug, ozanimod, reduced brain lesions in patients and lowered rates of disease relapse.
Quieting the Autoimmune Response
Our molecular biologists explore ways to “dial down” autoimmune responses without compromising the ability to stave off infection.
Restoring Nerve Cells
Calibr, our drug discovery division, is developing molecules that stimulate repair of the protective sheath covering nerve cells.
Improving Current MS Drugs
Scientists here are mapping signaling pathways to improve the efficacy of current treatments while reducing negative side effects.