Diabetes, Obesity & Metabolic Disorders

Our multidimensional strategy for addressing diabetes and related metabolic disorders holds promise for reversing a devastating epidemic.

Diabetes, obesity and metabolic disorders are overwhelming bodies and lives.

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We’re combining fundamental science, genomic medicine and digital health to address this nationwide epidemic.

A growing number of people are living with obesity, diabetes and related metabolic disorders. In the U.S. alone, more than 30 million people have diabetes—and another 84 million are prediabetic, on track to develop the disease within five years. At Scripps Research, we are working to address this urgent global health need. Our scientists are exploring how the body processes nutrients at the cellular level and how these systems become disrupted. We are identifying signaling pathways between the brain and the gut and understanding how to modulate these pathways to improve health.

The scientists and doctors at the Scripps Research Translational Institute add another layer of knowledge. They combine clinical research, genomic medicine, digital technologies and artificial intelligence to develop prevention strategies and improve patient health. Employing our cutting-edge technologies, one team uncovered distinct molecular “signatures” among people with obesity that predict their risk of developing diabetes. The findings give physicians a powerful new tool for helping patients adopt habits that prevent disease.

Diabetes and related metabolic disorders take a serious toll on patients, families and society at large. Our scientists are determined to stem the tide. We are developing a new understanding of these complex disorders and creating new treatments that can prevent or stop the physiological havoc they cause.

Diabetes Feature

Our Plan to Treat Diabetes

  • Optimize a Brain Hormone

    Scientists here discovered a brain hormone that triggers fat-burning, pointing to new approaches to treat obesity and diabetes.

  • Inhibit a Key Protein

    Scripps Research drug candidates that inhibit a protein linked with the body’s response to fat are undergoing evaluation.

  • Create Balance

    Our drug that reduces blood glucose, increases insulin sensitivity and improves glucose balance in animals may help humans.

  • Eliminate Side Effects

    We redesigned TZDs, drugs commonly used to reduce insulin, to eliminate a number of unwanted effects.

With an expanded understanding of diabetes and related metabolic disorders, we are delivering solutions for people around the world.

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