Deciphering Autoimmune Diseases

At Scripps Research, we’re identifying markers in our genetic blueprint that predispose us to autoimmune diseases.

When autoimmune diseases arise, the attack is personal.

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We’re finding ways to help bodies make peace with themselves.

The immune system is fine-tuned to detect and disarm foreign threats to our health. But what if parts of our own body are recognized as foreign? This phenomenon gives rise to autoimmune diseases, in which the immune system targets and attacks certain tissues—from our nerve cells, in the case of multiple sclerosis, to our joints, as seen in rheumatoid arthritis.

Autoimmune diseases are widespread, affecting more than 24 million people in the U.S., and often life-threatening or seriously debilitating. Understanding and treating these conditions ranks among the greatest medical challenges today. But scientists at Scripps Research are unraveling the mysteries, steadily uncovering the genetic and environmental triggers of an abnormal immune system, then devising novel ways to prevent the damage and reverse the disease.

Our immunology researchers have joined forces with our leaders in drug discovery and clinical science. Together, the team is translating discoveries about the core machinery of immune cells into groundbreaking therapies. This essential work seeks to reduce the global burden of autoimmune diseases and restore the lives of patients and their loved ones.

Autoimmune Disease Feature

Advancing Solutions for Autoimmune Diseases

  • Landmark Drugs

    Ozanimod, a Scripps Research drug in clinical trials, successfully blocks inflammation of the central nervous system.

  • Molecular Medicine

    Our scientists have identified a class of immune sensor proteins as the molecular cause of several autoimmune diseases.

  • A Streamlined Test

    Cutting-edge technology developed at Scripps Research holds promise for diagnosing autoimmune diseases with a simple blood test.

  • Genetic Sleuthing

    We’ve pinpointed a dysfunctional gene that weakens the gut’s lining in a subset of patients with Crohn’s disease.

The extraordinary scientists at Scripps Research invest their talents every day in unraveling the mysteries of autoimmune diseases.

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