By understanding the healthy brain, our scientists are learning to free it from addiction.

Addiction is a disease of the nervous system and repeated exposure to drugs or alcohol actually “rewires” the brain. Using cutting-edge technologies and scientific approaches, Scripps Research neuroscientists are working to understand both the healthy brain and the addicted brain at a molecular level. Because addiction is multifaceted, we are tackling it with multiple scientific approaches.

Our researchers are deciphering the physiological changes that drive excessive drinking and drug use and create vulnerability to relapse. We are finding effective ways to modulate the neurological effects of alcohol and drug abuse, thus minimizing the risk of overdose or death. And we are discovering how to help normalize the brain during recovery from alcoholism and addiction, thereby supporting patients on their return to wellness.

Already, we have developed promising experimental therapies for addiction. These therapeutic candidates include chemical vaccines to prevent overdoses from dangerous opioids, therapies designed to prevent addictive cravings during recovery and new pain-relieving compounds that avoid the life-threatening side effects of opioid drugs. By shining light on the underpinnings of addiction, we are discovering a brighter future for individuals and families affected by these disorders.